CoreCheck

Sample Type:

Blood

24 Biomarkers

This test empowers individuals to take charge of their health by providing accessible, accurate, and actionable wellness insights. It removes barriers to testing with a convenient, self-administered process, enabling users to prioritize their well-being from the comfort of home and embrace a proactive approach to health management.

CoreCheck analyzes 24 essential biomarkers to provide a comprehensive picture of your body’s health:

  • Hormones: Testosterone, Estradiol, Estrone, Estriol, Cortisol, Cortisone, Corticosterone, 1-deoxycortisol, 21-deoxycortisol, 11-deoxycorticosterone, Progesterone, 17-OH-progesterone, Androstenedione, Pregnenolone, DHEA, DHEA-S, DHT, Aldosterone
  • Thyroid and Vitamin Markers: TSH, 25-OH-Vitamin D3
  • Sex Hormone and Metabolic Indicators: Free Testosterone, SHBG, Insulin
  • Specialized Markers: PSA (for males) and LH (for females)

This self-administered test is a convenient and affordable option for gaining deeper insights into your health by measuring 24 key biomarkers. It’s designed to make the process easier while offering the flexibility to upgrade for a more comprehensive understanding when you’re ready.

To ensure accurate results for your CoreCheck.
please follow these simple guidelines:

  • Stay Hydrated: Drink plenty of water to keep your veins hydrated and make the blood draw easier.
  • Avoid Strenuous Activity: Refrain from intense exercise before the test to ensure precise measurements.
  • Early Detection: Identify potential health issues before they become serious problems.
  • Convenience: Test at your own pace, in the comfort of your home, with no need for clinic visits.
  • Holistic Health Monitoring: Get a full picture of your body’s wellness with 24 biomarkers.
  • Personalized Insights: Receive clear, actionable recommendations tailored to your health data.
  • Improved Wellness Management: Track progress and optimize your health through regular testing.
  • Trusted Accuracy: Results are validated by professionals, ensuring reliability and confidence.
Book a Call

How it works

1

Book Your Discovery Call

Schedule a call with our health experts to find the right test for your needs and get answers to any questions.

2

Collect Your Sample

Follow the simple instructions to collect your sample at home. The kit includes everything you need for a quick and easy process.

3

Get Your Results

Receive your comprehensive health report, covering 135+ biomarkers, with clear, easy-to-understand insights into your health.

4

Essential Health Support Every Step of the Way

Your first consultation with a wellness coach is included with this test. Receive personalized guidance on your results, access specialized doctors if needed, and rely on our alert system for immediate notifications of critical findings.

Coming soon, DIANA, our AI assistant, will provide even more insights to support your health journey.

5

Take Action

Use your personalized insights and Diana’s recommendations to make informed decisions, address potential concerns, and take control of your well-being.

Biomarkers

Androstenedione is a compound formed in the production of testosterone and estrogen. It is made in the adrenal glands and gonads (testes in males and ovaries in females). It is an active hormone with effects like those of testosterone. Testosterone is the major male sex hormone, or androgen. Androstenedione is metabolically converted to testosterone and estradiol in the body. Androstenedione levels also fluctuate during a woman’s menstrual cycle allowing the patient to better understand the rhythm of the cycle as well as identify hormone metabolism errors. For patients receiving HRT therapy, androstenedione is high when testosterone therapy is too high.

Estrone is a major estrogen metabolite. Levels begin to favor estrone in women as they approach menopause as they produce less estradiol. Monitoring the ratio between estradiol and estrone helps to understand the hormonal changes occurring in women throughout the aging process. This test could determine if you have an increased risk of menopause symptoms, such as hot flashes or low libido, which can be caused by low estrone. High levels could contribute to reproductive cancers, such as in the breasts or uterus.

This test is used to measure how much of this hormone, which is produced by the adrenal glands, is in the blood. This hormone plays an essential role because it helps to regulate the levels of potassium and sodium that are in the body. As a result, blood pressure levels are balanced, as are electrolyte levels. Two per cent (2%) of all hypertensions is caused by primary or secondary aldosteronism, which creates an excess of this hormone.

This test measures the level of cortisol in your blood, urine, or saliva to see if your levels are normal. Cortisol is a hormone that affects almost every organ and tissue in your body. It helps your body respond to stress, reduce  inflammation, regulate blood sugar and metabolism, and helps your body control blood pressure. Cortisol levels can be utilized to diagnose Cushing’s or Addison’s disease which are associated with excessive or low cortisol levels.

Stress can enhance the hypothalamus-pituitary-adrenal (HPI) axis, which causes the adrenal cortex to secrete corticosteroids to combat stress. As the two most important hormones, corticosterone and cortisol are widely used as the main biomarkers to reflect the degree of stress. The main effects are seen through the impact of stress on emotional memories as well as long term memory. Corticosterone is also the direct precursor of aldosterone giving insight into hormone metabolism. Cortisol is a steroid hormone produced by the adrenal gland. The human body stores cortisol in its inactive form, which is cortisone. The body can then quickly convert cortisone into cortisol in response to stress through an enzymatic pathway. Low levels of cortisone indicate adrenal fatigue, which means the body will not be able to produce cortisol on demand as needed in response to stress or pain.

Stress can enhance the hypothalamus-pituitary-adrenal (HPI) axis, which causes the adrenal cortex to secrete corticosteroids to combat stress. As the two most important hormones, corticosterone and cortisol are widely used as the main biomarkers to reflect the degree of stress. The main effects are seen through the impact of stress on emotional memories as well as long term memory. Corticosterone is also the direct precursor of aldosterone giving insight into hormone metabolism. Cortisol is a steroid hormone produced by the adrenal gland. The human body stores cortisol in its inactive form, which is cortisone. The body can then quickly convert cortisone into cortisol in response to stress through an enzymatic pathway. Low levels of cortisone indicate adrenal fatigue, which means the body will not be able to produce cortisol on demand as needed in response to stress or pain.

This test is useful in diagnosing patients with 11-beta-hydroxylase deficiency which is the second leading cause of congenital adrenal hyperplasia and primary (adrenal failure) or secondary (hypothalamic-pituitary ACTH deficiency) adrenal insufficiency.

DHEA is the most abundant adrenal steroid in the body. Sex steroids often circulate as DHEA where they are converted into androgens or estrogens in their target tissue. DHEA levels decline with age leading to a loss of energy and mental focus. DHEA levels determine the androgen to estrogen balance in women’s health and as a marker for polycystic ovary syndrome.

This test measures the level of a hormone known as Dihydrotestosterone . DHT is an androgen, which is 5x more androgenic than testosterone. Elevated levels in women can lead to irregular cycles, hirsutism and PCOS. Increased levels of DHT are one of the primary causes of hair loss in men and women. Furthermore, high levels of DHT can lead to elevated BPH in men.

Estradiol is the most potent form of estrogen in the body. This is a female hormone, produced primarily in the ovary. The amount of estrogen produced depends on the phase of the menstrual cycle. Men also produce estradiol, but only very small amounts. As women age, estradiol decreases and estrone increases leading to post-menopausal symptoms. Low levels of estradiol can lead to bone loss and osteoporosis.

This prenatal test is part of a triple marker or quad marker screening that helps detect birth defects. A quad marker screening test measures the hormones estriol and human chorionic gonadotropin (HCG). Various levels of estriol occur at different trimesters of pregnancy. Estriol is the weakest of the estrogen metabolites.

This test measures the level of vitamin D3 in your blood. Seventy (70%) of Americans are deficient in vitamin D. Abnormal levels of vitamin D can indicate bone disorders, nutrition problems, organ damage, or other medical conditions.

Pregnenolone is the parent hormone and the first hormone produced from the cleavage of the fatty acid side chain of cholesterol. Most hormones are produced from it. This test aids in diagnosing a condition known as Congenital Adrenal Hyperplasia (CAH). CAH is a group of disorders in which the body is deficient in one or more of the enzymes required to produce steroid hormones. Elevated levels of pregnenolone typically indicate that one or more of these enzymes is deficient. Low levels of pregnenolone have been associated with anxiety and pregnenolone supplementation has been studied in the treatment of cannabis use disorder.

Most often, testosterone is attached to proteins. The proteins prevent tissues from using the testosterone right away, which helps control the amount of “active” testosterone in the body. Testosterone that’s not attached to proteins is called free testosterone.

This test measures the level of testosterone in your blood. It is measured as total testosterone, either alone or in combination with free testosterone and/or bioavailable testosterone. Testosterone is mainly produced by the male testicles. It is also produced by the adrenal glands in both males and females and, in small amounts, by the ovaries.

This test is useful to diagnose patients with 11-beta-hydroxylase deficiency (second leading cause of congenital adrenal hyperplasia) and primary (adrenal failure) or secondary (hypothalamic-pituitary ACTH deficiency) adrenal insufficiency.

The 11-Deoxycorticosterone (DOC) test measures the levels of 11-deoxycorticosterone in the blood. This hormone is a precursor in the adrenal steroid hormone production pathway and plays a role in regulating sodium balance and blood pressure.

This test measures the level of progesterone in the blood which is a hormone made by a woman’s ovaries. Progesterone levels surge during ovulation and are part of what regulates the menstrual cycle. Progesterone plays an important role in pregnancy. It helps make the uterus ready to support a fertilized egg. Progesterone also helps prepare breasts for making milk. During pregnancy progesterone surges to cause the fertilized egg to implant into the uterus.

A cortisol deficiency can occur in people who lack the appropriate enzymes, which can lead to a buildup of 17-OH progesterone in the blood. High levels of 17-OH progesterone can indicate a condition called congenital adrenal hyperplasia (CAH). CAH is a glandular disorder that results in the adrenal glands being unable to create sufficient cortisol, and it may increase the production of male sex hormones called androgens. Furthermore, this hormone can be utilized to further determine a woman’s menstrual cycle.

This test identifies the source of excessive androgen; aids in the evaluation of androgen excess (hirsutism and/or virilization), including Stein-Leventhal syndrome and adrenocortical diseases as well as congenital adrenal hyperplasia and adrenal tumor. DHEA-sulfate works as a mild androgen in women and excess levels can lead to PCOS in women.

Thyroid Stimulating Hormone (TSH) is released from the pituitary in response to low levels of thyroid hormone. TSH communicates to the thyroid gland to release the thyroid hormones: Triiodothyronine (T3) and Thyroxine (T4). Thyroid hormones regulate metabolism. Quantifying TSH is the first step to diagnosing thyroid function and disorders.

SHBG’s primary role is to bind up androgens and transport them around the body. The higher the SHBG present the lower amount of free testosterone is available to interact with the body directly.

The Insulin Test measures the level of insulin, a hormone produced by the pancreas, in the blood. Insulin plays a critical role in regulating blood sugar (glucose) levels by allowing cells to take in glucose for energy or storage.

The Prostate-Specific Antigen (PSA) Test measures the level of PSA in the blood. PSA is a protein produced by the prostate gland, which is located below the bladder in men. Elevated PSA levels can be associated with prostate conditions.

The Luteinizing Hormone (LH) Test measures the level of LH in the blood. LH is a hormone produced by the pituitary gland that plays a crucial role in the menstrual cycle, ovulation, and fertility in females.